Vascular Aging in Chronic Kidney Disease: New Insights

Progerin present in 82 percent of CKD patients' arteries.

LMNA c.1824C>T mutation detected in 78 percent of CKD arteries.

Progerin frequency correlated with disease duration.

Increased endoplasmic reticulum stress in progerin-positive cells.

Findings suggest early vascular aging in CKD.

Higher ER stress and reduced VSMC density linked to progerin expression.

Mouse models showed similar findings to human tissue analysis.