Diagnosing soft tissue tumors is complex, but a new review by the College of American Pathologists highlights the utility of immunohistochemical (IHC) markers as surrogates for genetic alterations in improving diagnostic accuracy. With over 100 soft tissue tumor types, many pathologists may lack familiarity with these rare conditions. IHC offers a cost-effective, timely approach, especially in resource-limited settings, aiding in differentiating tumors with similar histological features. This review also discusses challenges and recommendations from Jason L. Hornick, a leading expert in surgical pathology.
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