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The Pathologist / Issues / 2025 / September / Rethinking Race in Prenatal Risk Calculations / Summary
Screening and monitoring Regulation and standards Genetics and epigenetics

Rethinking Race in Prenatal Risk Calculations

CAP research explores whether removing race from maternal serum screening equations can improve equity without compromising accuracy

By Jessica Allerton 09/19/2025 Discussion 4 min read
article Full Article Summary Notecard

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Prenatal serum screening is pivotal in assessing the risks of fetal genetic disorders, yet incorporating race in these evaluations can lead to false positives and unnecessary stress for expectant mothers. Ricky D. Grisson, from Brown University, highlights the need to reassess the use of race in predictive algorithms, arguing that racial disparities in health are not inherently biological but influenced by social factors. The College of American Pathologists is developing evidence-based guidelines to remove race-based adjustments from prenatal screening, which could reshape diagnostic protocols and promote health equity.

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About the Author(s)

Jessica Allerton

Deputy Editor, The Pathologist

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