HER2 mRNA Scores Correlate With Immunohistochemistry

Antibody-drug conjugates targeting HER2 are increasing.

The study evaluated HER2 mRNA scores from genomic assays.

1,524 patients with HER2-negative breast cancer data were analyzed.

Median mRNA scores increase with higher IHC categories.

28 percent of cases showed discordance between IHC and mRNA scores.

High nuclear grade and Ki-67 are predictors of discordance.

HER2 mRNA scoring may enhance identification of HER2-low cases.