Biomarker in Fibrotic Lung Disorders Explored in Study

SPARC identified as a prognostic marker in ILDs.

Strong expression in young fibrotic lesions; absent in older scars.

Study used spatial transcriptomics and cryobiopsy specimens.

Higher SPARC levels correlate with shorter overall survival.

SM2 module includes key genes like COL1A1, COL1A2, and COL3A1.

Integration with single-cell RNA data shows fibroblast activity.

SPARC serves as a surrogate marker for fibroblast activity in ILDs.