Tumor Budding Signals Higher Liver Cancer Mortality Risk

Over 500 cases of HCC studied from 1986-2022.

Ten or more tumor buds linked to high mortality.

Tumor budding identified as an independent risk factor for disease-specific mortality.

44.6 percent of surgically treated patients were bud-positive.

TSR showed no significant correlation with survival.

Detection sensitivity for tumor budding from biopsies was only 22 percent.