A study in Precision Clinical Medicine highlights significant genetic differences in hypertrophic cardiomyopathy (HCM) between Chinese and UK populations. Analysis of whole-exome sequencing from 593 Chinese patients and 1,232 UK patients revealed that 53 percent of the Chinese cohort carried rare variants in HCM-related genes, compared to 14 percent in the UK cohort. Both groups had similar rates of pathogenic variants. Ancestry-specific variants, including MYBPC3 c.3624del, were identified in the Chinese group, suggesting the need for population-specific data in diagnostic tools to improve accuracy for diverse populations.
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