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The Pathologist / Issues / 2025 / October / Pathology’s Precision Oncology Mandate / Summary
Oncology Precision medicine Biochemistry and molecular biology Laboratory management Omics Opinion and Personal Narratives Voices in the Community

Pathology’s Precision Oncology Mandate

The expanding role of pathologists as stewards of precision medicine for bladder cancer

By Eva Compérat, Markus Eckstein 10/23/2025 Discussion 5 min read

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Recent advancements in bladder cancer treatment emphasize the significance of precision medicine, driven by genetic biomarkers through next-generation sequencing (NGS). Researchers have identified key molecular profiles that guide therapeutic decisions for various bladder cancer stages. Guidelines encourage the integration of PD-L1 testing and FGFR3 gene analysis to facilitate better outcomes. However, challenges such as testing disparities and prolonged diagnostic times necessitate closer collaboration among oncologists, urologists, and pathologists to optimize patient care and treatment efficiency.

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About the Author(s)

Eva Compérat

Chair of Uropathology at the Medical University of Vienna, Austria.

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Markus Eckstein

Managing Senior Physician and Research Group Leader at the Institute of Pathology, University Hospital Erlangen, Germany.

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