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The Pathologist / Issues / 2025 / October / Mapping the Brain’s Hidden Nanotube Network / Notecards
Neurology Microscopy and imaging Digital Pathology

Mapping the Brain’s Hidden Nanotube Network

New imaging shows neurons may share signals and disease-related molecules through a previously unseen system of nanotubes

10/30/2025 News 1 min read
article Full Article Summary Notecard

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  1. Dendritic nanotubes (DNTs) are ultrathin structures enabling neuronal communication.

  2. DNTs facilitate calcium ion exchange between neurons.

  3. β-amyloid peptides can travel through DNTs in Alzheimer's disease models.

  4. Inhibiting DNT formation stops the spread of pathogenic proteins.

  5. Structural changes in DNT networks may occur early in disease progression.

  6. DNTs may provide insights into neurodegenerative pathology.

  7. This research expands the framework for studying neuronal signaling.

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