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The Pathologist / Issues / 2025 / October / From Spinal Taps to Simple Blood Draws Alzheimers Testing May Be Changing / Summary
Neurology Screening and monitoring Clinical care

From Spinal Taps to Simple Blood Draws: Alzheimer’s Testing May Be Changing

Findings suggest plasma biomarkers may outperform traditional methods in accessibility and ease

10/20/2025 News 2 min read
article Full Article Summary Notecard

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A recent study published in The Lancet Neurology demonstrates the accuracy of blood-based biomarkers in differentiating Alzheimer's disease from other neurodegenerative conditions. Conducted in Spain with 786 participants, the research analyzed proteins such as p-tau217, amyloid-β42/40 ratio, and neurofilament light chain (NfL) in blood samples. The findings suggest that plasma p-tau217, particularly when paired with other markers, could potentially reduce the need for invasive diagnostic methods, paving the way for easier and earlier testing in patients with cognitive concerns.

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