Finding the Origins of Lymphomas

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1. Mutation profiling distinguishes TdT-positive LBCL from B-ALL/LBL.

2. 31 cases were examined in the study.

3. DLBCLs carry mutations linked to follicular lymphoma.

4. B-ALL/LBL cases showed different mutational traits.

5. SHM target genes mutations were analyzed across cases.

6. Clonal ancestry suggested development from follicular lymphoma to HGBCL.

7. Genetic origin differs: germinal center-derived LBCL vs precursor B-cell for B-ALL/LBL.