Finding the Origins of Lymphomas

Mutation profiling distinguishes TdT-positive LBCL from B-ALL/LBL.

31 cases were examined in the study.

DLBCLs carry mutations linked to follicular lymphoma.

B-ALL/LBL cases showed different mutational traits.

SHM target genes mutations were analyzed across cases.

Clonal ancestry suggested development from follicular lymphoma to HGBCL.

Genetic origin differs: germinal center-derived LBCL vs precursor B-cell for B-ALL/LBL.