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The Pathologist / Issues / 2025 / October / Exosomes Break the Liquid Biopsy Barrier / Notecards
Oncology Clinical care Genetics and epigenetics

Exosomes Break the Liquid Biopsy Barrier

How tiny vesicles could transform cancer diagnostics far beyond the reach of ctDNA

10/22/2025 Discussion 6 min read
article Full Article Summary Notecard

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  1. Exosomes offer a novel approach in liquid biopsies for cancer detection.

  2. They release abundantly from living tumor cells, providing more genetic material.

  3. Improved sensitivity helps identify small cancer subclones earlier.

  4. Clinical applications in metastatic breast cancer show real benefits.

  5. Exosomal RNA enhances diagnostic assays alongside ctDNA.

  6. Exosomes protect RNA, improving its stability for analysis.

  7. Potential for use in various diseases beyond cancer is emerging.

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