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The Pathologist / Issues / 2025 / October / Bladder Cancers Immune Landscape Comes Into Focus / Notecards
Oncology Microbiology and Immunology Biochemistry and molecular biology Screening and monitoring

Bladder Cancer’s Immune Landscape Comes Into Focus

Immunohistochemical subtyping of muscle-invasive bladder cancer shows distinct PD-1 and PD-L1 patterns

By Kathryn Wighton 10/14/2025 News 2 min read
article Full Article Summary Notecard

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  1. Study on immunohistochemical classification of MIBC.

  2. Evaluated 124 urothelial carcinoma patients.

  3. Tumors classified as luminal, basal, other.

  4. PD-1 expressed in 70.5 percent of tumors.

  5. Higher PD-1 in luminal tumors (84.2 percent).

  6. PD-L1 observed in 40 percent of tumors, higher in basal.

  7. Study did not assess survival outcomes.

  8. Findings may guide therapeutic strategies.

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Kathryn Wighton

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