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The Pathologist / Issues / 2025 / October / Are Dolphins the New Alzheimer’s Sentinels? / Summary
Neurology Genetics and epigenetics Analytical science Biochemistry and molecular biology

Are Dolphins the New Alzheimer’s Sentinels?

New transcriptomic analysis links neurotoxin buildup in stranded dolphins to altered gene expression and hallmark Alzheimer’s pathology

10/28/2025 News 2 min read
article Full Article Summary Notecard

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Research published in Communications Biology reveals molecular signatures of Alzheimer’s disease (AD) in bottlenose dolphins exposed to harmful algal blooms (HABs) in Florida's Indian River Lagoon. A study analyzing brain tissue from 20 stranded dolphins over a nine-year period found elevated levels of neurotoxin 2,4-diaminobutyric acid during algal bloom seasons. The findings highlight how chronic exposure to algal neurotoxins might influence neurodegenerative processes and underscore dolphins as sentinel species for studying environmental impacts on neurological health.

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