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The Pathologist / Issues / 2025 / October / Antibody Choice Alters Breast Cancer Subtyping / Notecards
Oncology Research and Innovations Molecular Pathology

Antibody Choice Alters Breast Cancer Subtyping

Researchers compared MIB1 and SP6 antibodies for Ki-67 assessment in breast carcinoma.

By Kathryn Wighton 10/10/2025 News 1 min read
article Full Article Summary Notecard

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  1. Study published in Annals of Diagnostic Pathology.

  2. 17 percent discordance in Luminal HER2-negative tumors using MIB1 and SP6.

  3. Both antibodies show significant correlation in Ki-67 scoring (r = 0.755).

  4. No significant difference in mean proliferative indices (p = 0.288).

  5. Importance of standardizing antibody use in Ki-67 assessment to accurately classify tumors.

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Kathryn Wighton

Editor, Conexiant

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