A study published in Alzheimer's & Dementia reveals that the deterioration of perineuronal nets (PNNs) in the hippocampus's CA2 region could explain why Alzheimer's patients struggle to recognize familiar faces. Conducted by researchers from the University of Virginia and Virginia Tech using a mouse model, the study found that PNNs began breaking down at six months, coinciding with loss of recognition abilities. Treatment with a drug, GM6001, preserved PNNs and delayed recognition loss, suggesting potential new therapeutic approaches for Alzheimer's.
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