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The Pathologist / Issues / 2025 / November / When Gluten Sensitivity Isnt About Gluten / Summary
Endocrinology Biochemistry and molecular biology Screening and monitoring

When “Gluten Sensitivity” Isn’t About Gluten

Researchers continue to search for objective tools to distinguish true gluten sensitivity from other gut–brain interaction disorders

11/18/2025 News 2 min read
article Full Article Summary Notecard

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A recent review in The Lancet examines non-celiac gluten sensitivity (NCGS), a condition where patients experience symptoms attributed to gluten consumption despite negative celiac disease tests. Approximately 10 percent of adults report gluten sensitivity, yet only 16-30 percent exhibit consistent symptoms in clinical trials, influenced by dietary variables like FODMAPs. The absence of validated biomarkers complicates diagnosis, which currently relies on exclusion of celiac disease and wheat allergy. The authors advocate for developing new biomarkers to enhance diagnostic accuracy and underscore the need for a collaborative approach among healthcare providers.

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