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The Pathologist / Issues / 2025 / November / What Causes Long COVID Brain Fog / Notecards
Neurology Biochemistry and molecular biology Research and Innovations Microscopy and imaging

What Causes Long COVID Brain Fog?

Researchers found increased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor density across the brain in patients with cognitive long COVID.

By Kathryn Wighton 11/11/2025 News 2 min read
article Full Article Summary Notecard

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  1. Cognitive impairment affects over 80 percent of long COVID patients.

  2. The study focuses on changes in AMPA receptors in the brain.

  3. [¹¹C]K-2 PET imaging was used to assess receptor density.

  4. 30 Cog-LC patients and 80 healthy controls were enrolled.

  5. Higher AMPA receptor density correlated with cognitive deficits.

  6. Study suggests a potential for new diagnostic tools.

  7. Findings may improve treatment options for cognitive long COVID.

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About the Author(s)

Kathryn Wighton

Editor, Conexiant

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