ASA-PD allows visualization of nanoscale α-synuclein in brain tissue.
It detects early protein aggregation related to Parkinson's disease.
The method combines autofluorescence suppression with microscopy.
Analyzed 1.2 million aggregates from post-mortem samples.
Reveals changes in oligomeric species in PD, suggesting early disease features.
Not a diagnostic tool; aims to inform future biomarker development.
Potential applications for other related disorders.
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