A recent study in Nature Medicine reveals that indicators of multiple sclerosis (MS) can manifest years before the clinical symptoms appear. Researchers utilized high-throughput serum proteomics to uncover that myelin injury starts approximately seven years prior to symptom onset, followed by axonal injury one year later. Changes related to astrocytes, typically associated with neuroinflammation, arise only at symptom onset. This suggests that demyelination is an early event in MS pathogenesis, with implications for early detection and disease monitoring.
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