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The Pathologist / Issues / 2025 / November / Inside the Race to Detect Neurodegenerative Disease Early / Summary
Neurology Biochemistry and molecular biology Genetics and epigenetics Technology and innovation

Inside the Race to Detect Neurodegenerative Disease Early

Unlocking a new frontier in diagnosing and understanding complex brain diseases long before symptoms appear

By Jessica Allerton 11/27/2025 Discussion 3 min read
article Full Article Summary Notecard

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Advancements in neurodegenerative disease diagnostics play a crucial role in enhancing patient outcomes. Amprion, led by CEO Russ Lebovitz, has shifted its focus from Creutzfeldt-Jakob disease to developing diagnostics for prevalent conditions like Parkinson's and Huntington's disease. Their SAAmplify-αSyn test has shown remarkable accuracy, detecting biomarkers years before clinical diagnosis. This innovation could also pave the way for broader applications in Huntington’s diagnostics, employing protein misfolding assays to improve mutation detection and treatment precision.

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About the Author(s)

Jessica Allerton

Deputy Editor, The Pathologist

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