Researchers have developed a novel taste-based influenza screening method utilizing viral neuraminidase activity to activate a chemical sensor. This approach focuses on N-acetylneuraminic acid derivatives connected to thymol, ensuring selectivity for viral neuraminidase. Two sensor variants were created, with the methylated α-linked sensor successfully responding only to viral neuraminidase while maintaining structural stability and cytotoxicity safety. These advancements could enable low-cost, rapid influenza testing, pending further evaluation against patient outcomes.
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