A new ultrasound-assisted microfluidic system may improve the detection of circulating tumor cells (CTCs), which are vital for early cancer diagnosis.
Whilst CTCs serve as valuable cancer biomarkers, they have proved difficult to separate from samples, typically requiring large sample sizes and complex sample preparation and equipment.
Published in Physics of Fluids, the study introduces an advanced device using standing surface acoustic waves (SSAWs) and a specialized microfluidic channel to enhance CTC separation from blood samples.
Scientist Naser Naserifar explained the system, “We combined machine learning algorithms with data-driven modeling and computational data to fine-tune a system for optimal recovery rates and cell separation rates. Our system achieves 100 percent recovery at optimal conditions, with significant reductions in energy consumption through precise control of acoustic pressures and flow rates.”
This lab-on-a-chip technology could improve real-time liquid biopsy applications by enabling high-precision CTC isolation. “The technology promises to improve CTC separation efficiency and open new possibilities for earlier and more effective cancer diagnosis. It also paves the way for microengineering and applied AI in personalized medicine and cancer diagnostics," said co-author Afshin Kouhkord.
Future research aims to integrate this system into point-of-care diagnostics.
Newsletters
Receive the latest pathology news, personalities, education, and career development – weekly to your inbox.
