RNA Testing Uncovers Hidden Gene Fusions in AML

RNA-based assay enhances NGS for AML.

89 fusions identified in 601 AML cases.

23 fusions were cryptic by karyotype.

Gene fusions define AML molecular subtypes.

Integration of RNA testing could improve diagnostics.

Findings presented at AMP annual meeting.

The approach aligns with WHO and ICC classifications.

Essential for comprehensive AML diagnostics.