Microbiology & Immunology Infectious Disease Omics Microbiology and Immunology Research and Innovations

Targeted DNA Mutation System Developed for E. coli

Circular plasmid replication could help study antibiotic resistance and improve diagnostic assays

08/27/2025 News 1 min read

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T7-ORACLE introduces high mutation rates in plasmids.
It targets specific genes without altering the host genome.
Mutation rate is 100,000 times higher than normal.
Potential applications in diagnostics and predicting antibiotic resistance.
Safe testing protocols due to plasmid-focused mutations.