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The Pathologist / Issues / 2025 / Aug / Introducing Mass Spectrometry Histochemistry / Summary
Histology Career Pathways Professional Development Analytical science Microscopy and imaging Technology and innovation Histology Molecular Pathology

Introducing Mass Spectrometry Histochemistry

Pathology’s future lies in unlocking the molecular signals preserved in FFPE tissue

By Peter Verhaert 08/07/2025 Discussion 6 min read
article Full Article Summary Notecard

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Mass spectrometry histochemistry (MSHC) significantly enhances pathology by enabling high-resolution imaging of archived formalin-fixed paraffin-embedded (FFPE) tissues. This innovative technique can discern complex biomolecules from extensive biobank archives, challenging prior beliefs about FFPE limitations. MSHC not only fits seamlessly within existing laboratory workflows but also opens avenues for retrospective disease typing, clinical validation, and predictive testing, promising to transform diagnostic practices in pathology.

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About the Author(s)

Peter Verhaert

Founder of ProteoFormiX, Special Lecturer Translational Cell & Tissue Research Unit at the University of Leuven Faculty of Medicine, Belgium, and Visiting Professor at the University of Witwatersrand, South Africa

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