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The Pathologist / Issues / 2025 / Aug / Introducing Mass Spectrometry Histochemistry / Notecards
Histology Career Pathways Professional Development Analytical science Microscopy and imaging Technology and innovation Histology Molecular Pathology

Introducing Mass Spectrometry Histochemistry

Pathology’s future lies in unlocking the molecular signals preserved in FFPE tissue

By Peter Verhaert 08/07/2025 Discussion 6 min read
article Full Article Summary Notecard

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  1. MSHC allows analysis of archived FFPE tissues.

  2. Traditional MSI workflows misalign with clinical pathology needs.

  3. MSHC provides improved molecular specificity.

  4. MSHC can operate alongside existing immunohistochemistry.

  5. Potential for retrospective studies enriches biomarker discovery.

  6. Offers insights into aggressive vs. indolent tumor types.

  7. Expands the utility of archived biobank samples.

  8. Needs community engagement for successful integration into diagnostics.

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About the Author(s)

Peter Verhaert

Founder of ProteoFormiX, Special Lecturer Translational Cell & Tissue Research Unit at the University of Leuven Faculty of Medicine, Belgium, and Visiting Professor at the University of Witwatersrand, South Africa

More Articles by Peter Verhaert

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