An international research team conducted a major study analyzing somatic mutation rates across various human tissues, utilizing 3,127 microdissected samples from 941 donors. The study, published in Nature, is part of the Human Cell Atlas initiative and employs advanced whole-genome sequencing techniques. Key findings reveal substantial variation in mutation rates by tissue type and age, with environmental factors influencing mutation patterns. This research provides a foundational reference for understanding mutation accumulation in normal tissues and may enhance understanding in fields such as cancer development and regenerative medicine.
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