Human Cell Atlas Adds Somatic Mutation Baselines

Study analyzed somatic mutations across 41 tissue types.

Employed whole-genome sequencing on samples from 941 donors.

Identified over 70 distinct mutational signatures.

Mutation rates vary significantly by tissue type and age.

Environmental factors influence mutation patterns in specific tissues.

Findings aid in cancer research, aging studies, and regenerative medicine.

Study uses advanced techniques like laser-capture microdissection.

Data to contribute to broader tissue and cell atlases.