A recently published manifesto in Diagnostic Pathology outlines a framework for integrating digital twin (DT) technology into clinical pathology laboratories, authored by an international team of pathologists and engineers. This paper analyzes traditional versus DT-enabled workflows, emphasizing diagnostic efficiency and operational performance. DTs, which are virtual models of physical systems, could revolutionize lab operations from accessioning to diagnosis, addressing issues like labeling errors and diagnostic delays. The authors recommend phased implementation, starting with high-impact areas, and call for further research to assess the long-term impacts of DTs in pathology.
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