A recent study in the Journal of Cachexia, Sarcopenia, and Muscle explored how growth differentiation factor 15 (GDF-15) and the difference between cystatin C- and creatinine-based estimated glomerular filtration rates (eGFRdiff) impact diabetes mellitus patients over five years. The research involved 638 Japanese adults, revealing that lower eGFRdiff correlated with a significantly increased risk of chronic kidney disease progression, while higher GDF-15 levels were linked to a 235% higher mortality risk. These biomarkers may improve risk stratification in diabetic kidney disease.
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