A study published in Pathology establishes continuous reference intervals (RIs) for serum immunoglobulin E (IgE) levels in children, differentiating between those with and without allergic conditions. Conducted on 441 participants in Melbourne, Australia, the research found that IgE levels in allergic children were over 30 times higher than non-allergic peers. This study highlights the need for age-specific RIs due to significant variations and suggests the methodology can be adapted for local laboratory verification of population-specific RIs.
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