Recurrent Skin Tumor
Hematoxylin-eosin section (a) demonstrates a recurrent tumor from the leg of a 91-year-old man. The tumor was diagnosed two years previously as an angiosarcoma and treated by radical excision. The recurrent tumor avidly expressed CD31 and was nonreactive for smooth muscle actin, SOX-10, Melan A, and CD10. It was positive for HHV-8 (b).
What is the most likely diagnosis? A. Angiosarcoma B. Kaposiform hemangioendothelioma C. Kaposi sarcoma D. Spindle cell hemangioma E. Spindle cell hemangioendothelioma
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Answer to last month’s Case of the Month… D: Yolk sac carcinoma The tumor shows several histologic growth patterns, forming among others reticular, tubular and papillary structures, and even the so called Schiller-Duval bodies. The blood submitted to the laboratory after surgery contained increased amounts of alpha-fetoprotein. Submitted by Da Zhang, The University of Kansas, Kansas City, USA.
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