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March 2016
In this issue our Upfront topics include the genetics of addiction, a call for research into microbiological causes of Alzheimer’s disease, and the progress of the Zika virus. Our Feature invites two founders of precision medicine institutes to share their experiences and their views on the future of personalized care. In Practice tackles cystic fibrosis screening in non-white populations, and NextGen looks at a test that can diagnose all known viral infections. In Profession, five experts discuss landmark papers of 2015, and we Sit Down With James Westgard, Emeritus Professor in Pathology and Laboratory Medicine at the University of Wisconsin Medical School and President of Westgard QC, Inc.
Field of Genes
March 30, 2016
The Penn State Hershey Institute for Personalized Medicine benefits from a unique “build it as you need it” growth pattern
1 min read
Young But Powerful
March 30, 2016
Penn Medicine’s Center for Personalized Diagnostics is on a mission to improve patient care using the power of genomics
1 min read
A Tale of Two Cities
March 30, 2016
How is fierce ambition translated into the reality of building two world-class personalized healthcare institutes?
1 min read
Getting Personal
March 30, 2016
Patient-derived xenografts are a valuable tool for the oncological drug development of the future
1 min read
The Problem With Panels
March 30, 2016
Newborn screening programs that seek out common mutations often fail to diagnose cystic fibrosis in non-white populations. Why – and what can we do?
1 min read
Viruses Face the Ultimate Test
March 29, 2016
Shotgun sequencing is a powerful tool in microbial genomics, but viral genomes have proven tough to crack. Enter ViroCap and its ability to enhance shotgun sequencing to detect the vast majority of viruses infecting humans and animals in a single test. For viruses, is there anywhere left to hide?
1 min read
Collagen and the Colon
March 29, 2016
Miguel’s landmark paper: R Soret et al., “A collagen VI-dependent pathogenic mechanism for Hirschsprung’s disease”, J Clin Invest, 125, 4483–4496 (2015). PMID: 26571399.
1 min read
Diagnosis: Digital
March 29, 2016
Liron’s landmark paper: DR Snead et al., “Validation of digital pathology imaging for primary histopathological diagnosis”, Histopathology, [Epub ahead of print] (2015). PMID: 26409165.
1 min read
Hyperspectral Disease Diagnosis
March 29, 2016
Peter’s landmark paper: JT Kwak et al., “Improving prediction of prostate cancer recurrence using chemical imaging”, Scientific Reports 5, Article number: 8758 (2015). PMID: 25737022.
1 min read
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