Although only the 12th most common cancer worldwide (1), pancreatic cancer has gained increasing attention over the last few years. High-profile figures like Steve Jobs and Randy Pausch have shone a bright spotlight on the disease, but despite the increase in research interest, progress remains slow. Why? A combination of factors: the potential causes of the disease are not well understood, screening techniques are imperfect, chemotherapy and radiation treatments have limited success, and the mortality rate is high – only about 6 percent of patients survive five years (2), and that number drops to 1 percent after 10 years (3). But these are not just dismal statistics – they are a call to arms for researchers, and lately, that call has been answered extensively, with new ideas for diagnosis, prognosis and treatment seeming to arrive every day. In this series of articles, we speak with some of those scientists at the forefront of this research to learn more about what’s being done. Will we soon see those survival statistics improve? It’s still early days for the new wave of pancreatic cancer breakthroughs, but one thing’s for sure – the promise is most certainly there.
Tapping a Rich Vein by Christopher Chapman
New Ab-ilities in Imaging by Michael Schubert
Surprising Subtypes by Michael Schubert
Friend or Foe? by Anne Marie Lennon
(Chemo)resistance Is Futile by Michael Schubert
Breaching Cancer’s Defenses by Ingunn Stromnes
An Epigenetic Epiphany by Michael Schubert
Building a Better Mousetrap by Michael Schubert
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References
- J Ferlay et al. “GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11”, (2013). Available at: http://globocan.iarc.fr. Accessed November 23, 2015. M Sant et al., “EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary”, Eur J Cancer, 45, 931–991 (2009). PMID: 19171476. Cancer Research UK, “One-, five- and ten-year survival for pancreatic cancer”, (2014). Available at: http://bit.ly/21d4tyO. Accessed November 23, 2015.