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In the final issue of The Pathologist for 2022, we explore how genomic medicine is creating a rare disease “revolution.” Learn how genomics is progressing at rocket speed; why rapid, reliable, and accessible sequencing is life-changing for patients; and just how AI and awareness fit into this quickly evolving picture. Also in this issue, we hear how The University of Texas Medical Branch is working to solve dwindling access for benign hematology patients, why pathologists need to talk about tech, and how overcoming lung cancer treatment resistance requires predictive biomarkers. And it doesn’t stop there: the importance of the phlebotomist’s poke plan; existing AI in the lab; preparing for another pandemic; and Sitting Down With… Julie Feldstein, Chief Pathologist at HistoWiz, on the jump from academia to industry.