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December 2018 Issue of The Pathologist

In this issue we explore how environmental factors from decades ago can have a profound impact on gene expression today. Focusing on the Dutch Hongerwinter of 1944, Mary J. Wirth examines the unusually high prevalence of heart disease and metabolic disorders that children of the era exhibit, and asks whether we can manipulate our epigenome to live longer, healthier lives. Also in the December issue, read about compounds that inhibit the aggregation of a protein linked to Parkinson’s disease, the evolution of epigenetic biomarkers, and how to succeed in collaboration and communication. We also sit down with Wendy L. Frankel, Kurtz Chair and Distinguished Professor of Pathology and Chair of the Department of Pathology at The Ohio State University Wexner Medical Center, Columbus, USA.

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Articles featured in this issue

Outside the Lab Profession

A Roster of Unsung Heroes

| Michael Schubert

It’s time to showcase the entire field of lab medicine – not only pathologists, but also other laboratory professionals whose work is equally vital

Subspecialties Biochemistry and molecular biology

Identifying Parkinson’s Inhibitors

| Luke Turner

An innovative approach aims to find the most effective inhibitors of α-synuclein protein aggregation, which is a leading cause of Parkinson’s disease

Outside the Lab Cytology

Nephrology in Your Pocket

| Luke Turner

An award-winning app aims to enhance the nephrology learning experience, facilitate discussion, and attract new people to the field

Diagnostics Analytical science

Sensing the Tiniest Change

| Menno Prins

New biomarker sensing technology can detect miniscule concentrations of molecules in the blood to assist with patient monitoring

Subspecialties Biochemistry and molecular biology

Journey to the Center of the Cell

| Luke Turner

A 3D model allows scientists to view live human cells in an unprecedented way, using an algorithm to display the shape and location of its structures

Inside the Lab Digital and computational pathology

Think Before You (Don't) Print

| Tormod Schüßler

Specimen misidentification is not uncommon in pathology – but specialized printing solutions can reduce the likelihood of error

Inside the Lab Digital and computational pathology

People Power and Machine Learning

| Geoff Twist

A collaboration between industry, academia, and the clinic could lead to more efficient, more personalized cancer diagnosis and treatment

Inside the Lab Clinical care

Test Utilization – More Than Just a Buzzword

| E. Blair Holladay

Our job as pathologists is to ensure the quality and efficiency of patient testing by educating both ourselves and our clinical colleagues

Subspecialties Analytical science

A Lasting Legacy

| Mary J. Wirth

A story of war, famine, epigenetics, and how all three colluded to change the phenotype of a generation of babies – and beyond

Inside the Lab Microscopy and imaging

The Innovators 2018

Leading industry innovators showcase their newest and most advanced solutions for pathology and laboratory medicine

Diagnostics Genetics and epigenetics

The Evolution of Epigenetic Biomarkers

| Niamh Buckley, Laura Feeney, James Beirne, and Paul Mullan

Markers such as DNA methylation, analyzed by liquid biopsy, may improve on ovarian cancer testing options like gold standard CA125

Diagnostics Genetics and epigenetics

Thinking Outside the (Genome) Box

| Jason Mellad

Epigenetics may combine with liquid biopsy to offer an effective way of detecting early-stage cancers and recurrences

Outside the Lab Profession

Twin Challenges: Collaboration and Communication

| Fred Bosman

Collaboration and communication are often confused with one another. In fact, they are quite distinct, and pathologists must become skilled at both

Outside the Lab Profession

Genetics, GI Pathology, and Golden Retrievers

| Michael Schubert

We sit down with GI and liver pathologist Wendy L. Frankel to discover how pathology's attractiveness altered her ambition to become a surgeon

Other issues of 2018