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November 2018 Issue of The Pathologist

This issue features an in-depth exploration of what it takes to be a successful laboratory director. We interview accomplished lab leaders Paul Bachner and David Wilkinson, who share their wealth of leadership experience to advise current laboratory directors and inform those of the future. Also in the November issue, read about a magnetic wire that captures circulating tumor cells, the case for pathologist-driven diagnostic management teams, and the life lessons of The Power List’s 2018 winner, Fátima Carneiro. Additionally, we sit down with Malak Abedalthagafi, Assistant Professor of Genomics and Neuropathology at King Abdulaziz City for Science and Technology.

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Articles featured in this issue

Inside the Lab Profession

The Missing Act

With so many festivals and events aimed at sharing science with the public, why is laboratory medicine so often absent?

Outside the Lab Histology

Case of the Month

Can you diagnose this 73-year-old female’s oval lesion of the scalp?

Inside the Lab Clinical care

Characterizing Cancer

| Luke Turner

Digital spatial profiling technology may enable researchers to identify biomarkers that indicate how patients with high-risk melanoma will respond to treatment

Subspecialties Biochemistry and molecular biology

An Untrustworthy Myeloma Assay?

The serum free light chain assay for myeloma may miss as many as one in four cases of lambda chain-associated disease, so additional testing is advised

Diagnostics Biochemistry and molecular biology

Muscling in on Malignant Hyperthermia

| Bradley Launikonis

This dangerous condition can cause sudden death during surgery – but until now, testing has been unreliable and often painful and invasive

Inside the Lab Clinical care

Gone Fishing

A combination of magnetic particles that bind circulating tumor cells and a magnetic wire that samples them directly from the vein could lead to earlier diagnosis

Inside the Lab Cytology

OK Google: Scan This Slide

| Luke Turner

Google’s AI team have developed an algorithm that can improve the accuracy of breast cancer diagnoses

Outside the Lab Biochemistry and molecular biology

Pre-Empting Relapse

| Luke Turner

A new DNA test that can detect treatment-resistant mutations could prove crucial for patients with acute myeloid leukemia, providing an early indication that targeted therapeutic intervention is needed

Inside the Lab Clinical care

Leading the Pack

| Marisa Saint Martin

Pathologists hold the key to diagnostic management teams – and diagnostic management teams have a lot to contribute to patient care

Inside the Lab Clinical care

Pathologists Versus AI

| Holger Lange and Cris Luengo

Not only is artificial intelligence not intended to replace pathologists – at the moment, it can’t function without them!

Outside the Lab Profession

Leadership Is an Opportunity and Our Obligation

| E. Blair Holladay

To stay at the forefront of medicine, pathologists and laboratorians need to become drivers for change in our own institutions

Outside the Lab Laboratory management

A Masterclass in Leadership

| Paul Bachner and David Wilkinson

Paul Bachner and David Wilkinson share their experience and advice on being the best lab director you can be

Outside the Lab Clinical care

The “We” in Team

| Judith Hugh

What exactly is a multidisciplinary team – and what is the pathologist’s role in it?

Inside the Lab Biochemistry and molecular biology

One Drop at a Time

| Alexander Dobrovic and Cloud Paweletz

When seeking the greatest benefit from liquid biopsy, droplet digital PCR can help by offering speed, sensitivity, and absolute quantitation

Inside the Lab Clinical care

Biochip Breakthrough

| Luke Turner, Arjang Hassibi

With antimicrobial resistance an ever-increasing threat to modern medicine, a new breakthrough may rapidly identify drug-resistant microbe strains to ensure effective treatment

Outside the Lab Clinical care

Peer-to-Peer, Featuring Fátima Carneiro

| Fátima Carneiro and Ivan Damjanov

From cell biology to gastrointestinal and liver pathology, Fatima Carneiro has achieved great heights in the field. She talks about her achievements, the problems facing the discipline, and how young pathologists can succeed

Outside the Lab Genetics and epigenetics

A Global Citizen

We sit down with Malak Abedalthagafi to talk about the biggest issues facing pathology and how she has adapted to working around the globe

Inside the Lab Clinical care

From Dream to Deployment

| Sponsored by Leica

Leeds Teaching Hospitals NHS Trust and Leica Biosystems have formed a unique partnership to make a 100% digital pathology service a reality

Other issues of 2018