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December 2016 Issue of The Pathologist

“Welcome to our December issue. Our Upfront articles this month deal with guidance on laboratory-developed assays, HER2 testing, and quality assurance in Canadian pathology. In My View asks whether we’re letting our fascination with genomics blind us to non-genomic precision medicine tools. Our very special Feature is the 2016 Power List, celebrating the “rising stars” of pathology and laboratory medicine – nominated by you. In Practice discusses the applicability of mass spectrometry to diagnostics, and NextGen explores structured illumination microscopy and microbiome-modeling software. We Sit Down With Greek molecular pathologist Vassilis Gorgoulis.

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Articles featured in this issue

Outside the Lab Profession

Holiday, Celebrate

| Fedra Pavlou

Stop press… This year’s Power List is here and we’re celebrating pathology’s rising stars

Outside the Lab Regulation and standards

FDA LDT Guidance Delayed

| William Aryitey

The FDA extends its timeline for LDT guidance to ensure the bill is the best it can be

Diagnostics Oncology

How to HER2

| William Aryitey

CAP, ASCP, and ASCO issue joint HER2 guidelines for gastroesophageal adenocarcinoma

Outside the Lab Profession

The Fugacity of Pathology’s Capacity

| William Aryitey

Cancer Research UK’s pathology report highlights impending capacity problems

Outside the Lab Quality assurance and quality control

Canada’s Quality Commitment

| William Aryitey

Canada publishes its first ever set of guidelines for interpretive pathology

Subspecialties Analytical science

Detecting Dangerous Deposits

| Joanna Cummings

Tandem mass spectrometry could improve detection of amyloidosis-causing proteins

Outside the Lab Liquid biopsy

Flesh or Blood

| William Aryitey

Liquid biopsies: increasingly a quick, noninvasive alternative to traditional techniques

Diagnostics Technology and innovation

Biomarkers, Sweat and Tears

| William Aryitey

A novel wearable biofluidic device could noninvasively analyze biomarkers in sweat

Subspecialties Profession

Image of the Month

This painting shows the excised rectum of a patient with ulcerative colitis.

Outside the Lab Precision medicine

The (Genomics) World Is Not Enough

| Joe Olechno

Precision medicine’s focus on the genome may be blinding us to vital non-genomic tools

Diagnostics Oncology

Beyond Cancer Imaging

| Zaver M. Bhujwalla

Exploring the new world of theranostics that integrates cancer diagnosis with treatment

Inside the Lab Clinical care

21st Century Diagnostics

| Jasmina Casals-Terré

Microfluidic innovations promise a new generation of POCT tools for the pathologist

Outside the Lab Profession

The Power List 2016

Honoring the movers and shakers of the next generation of pathologists

Outside the Lab Analytical science

Mass Spec Targets Routine Diagnostics

| R Neil Dalton & Charles Turner

Exquisite sensitivity and specificity gives MS the edge in clinical applications

Inside the Lab Analytical science

Ovarian Cancer’s Early Warning System

| Robert Graham

MS identifies serum protein thresholds that could warn of disease before symptoms develop

Outside the Lab Microscopy and imaging

Finely Tuned Microscopy

| Jonathan Nylk & James Pullman

SIM could let pathologists “see” glomerular structures, aiding kidney disease diagnosis

Inside the Lab Technology and innovation

Getting Rid of the Guesswork

| William Aryitey

A new software tool, MDSINE, predicts how a simplified microbiome reacts to probiotics

Subspecialties Profession

Seeing the Wood and the Trees

| Fedra Pavlou

Vassilis Gorgoulis, Director of the Laboratory of Histology-Embryology, National and Kapodistrian University of Athens

Outside the Lab Genetics and epigenetics

NGS: Driving a Revolution in Cancer Diagnostics and Treatment Management

Growing demand for multiple biomarker analysis gives diagnostics labs new challenges

Other issues of 2016