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In this issue, we delve into the history of disease, to learn how the field of paleopathology uses human remains to inform current laboratory practice. Read our feature to find out how advances in technology are allowing us to discover more than ever about the ailments of our ancestors. Also in this issue, read about the fight against resistance in bloodstream infections, the potential of AI in pathology, and the daunting process of diagnosing brain tumors. Additionally, we sit down with James Wilson, a gene therapy expert from the University of Pennsylvania.