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October 2018 Issue of The Pathologist

In this issue, we delve into the history of disease, to learn how the field of paleopathology uses human remains to inform current laboratory practice. Read our feature to find out how advances in technology are allowing us to discover more than ever about the ailments of our ancestors. Also in this issue, read about the fight against resistance in bloodstream infections, the potential of AI in pathology, and the daunting process of diagnosing brain tumors. Additionally, we sit down with James Wilson, a gene therapy expert from the University of Pennsylvania.

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Articles featured in this issue

Outside the Lab

A Community of Equals

What makes pathology and laboratory medicine unique? Everyone, from trainee to department chair, receives respect

Outside the Lab

Case of the Month

Can you diagnose this 29-year-old’s painful subungual tumor?

Inside the Lab

Shining a Brighter Light

| Srikanth Singamaneni

A new “plasmonic patch” can enhance fluorescence-based detection and imaging for research and in the clinic

Inside the Lab

Fluid Evidence

Liquid biopsy can help us appropriately treat patients with anti-PD-L1 immunotherapies, and ddPCR enables ongoing monitoring and adjustment of treatment

Inside the Lab

A Biomarker for Brain Injury

Measuring the levels of two brain proteins in the blood can yield insight into which TBI patients require CT scanning or surgery

Outside the Lab

Fighting Resistance in Bloodstream Infections

| Luke Turner

When bacteria become resistant to the last line of defense, rapid detection and treatment is more important than ever. A new assay can help with treatment selection for carbapenem-resistant infections

Outside the Lab

Intelligent Pharma Partners

| Holger Lange and Cris Luengo

How combining their efforts with those of the pharmaceutical industry can help pathologists make a business case for AI

Outside the Lab

Automation Inevitable?

| Randy Van Ommeren, Kevin Faust, and Phedias Diamandis

As deep learning moves into the pathology sphere, the way we do our jobs will change – but we have yet to determine exactly how

Inside the Lab

It Takes a Village

| E. Blair Holladay

From drawing blood to managing laboratories, there is a whole network of professionals working together to provide optimal patient care

Diagnostics

Connecting Past to Present

| Niels Lynnerup

Niels Lynnerup explains the discipline of paleopathology and what benefits it has to offer pathology in the clinic or in the research laboratory

Diagnostics

Bioarcheology: Peopling the Past

| Jane Buikstra

Where did paleopathology come from? Where is it going next? And, most importantly, how can clinical and paleopathologists work together to benefit both fields?

Diagnostics

What’s in a Brain?

| Jason Karamchandani

Jason Karamchandani explains how anatomic pathologists can identify and distinguish between the most common intracranial neoplasms of adulthood

Diagnostics

Searching Is Intelligence

| Hamid Tizhoosh

Despite extensive discussion of the benefits of artificial intelligence in pathology, few are talking about one major advantage – image search and retrieval

Outside the Lab

A Question of Cancers

| John Srigley

The ICCR works with pathologists and groups worldwide to develop standardized guidelines for the diagnosis and reporting of various cancer types

Outside the Lab

From Bench to Bedside and Back Again

| Roisin McGuigan

Sitting Down With James Wilson, Rose H. Weiss Professor and Director, Orphan Disease Centre, Profession of Medicine and Pediatrics, University of Pennsylvania

Outside the Lab

Antibiotic Test Results – Done Right

| Sponsored by Beckman Coulter

An advanced system can identify pathogens and detect broad-ranging resistance, allowing pathologists to select the most appropriate drugs with accuracy and speed

Other issues of 2018