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“Welcome to our October issue. This month, we focus our Upfront articles on superbugs in humans, hens and hogs. In My View authors comment on the value of quality control, immunophenotyping, and sampling serous effusions for cancer diagnosis. Our Feature faces the challenge of antimicrobial resistance and stewardship head-on. In Practice tells us about social media’s rising role in diagnostics and epidemiology, and NextGen discusses virtual reality in surgical pathology education and a potential breath test for IBS. Profession shows how art can forge connections between patients and pathologists, and we Sit Down With John Gurdon, Nobel Prize-winning biologist at the University of Cambridge.”