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In July/August’s issue of The Pathologist, it’s time for blast-off as we launch our space-themed 2022 Power List – celebrating 75 inspiring and influential individuals in pathology and laboratory medicine. Also in the issue, learn about how (and why) to have fun during residency, how a pathology message pool can help put patients’ minds at ease, and the importance of appraising new scientific discoveries with caution. And much more: understand the barriers preventing single-cell sequencing from reaching the clinic; the positive implications of the 21st Century Cures Act; a deep dive into the numbers behind our Power List; and an interview with author and museum curator Carla Valentine.