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Welcome to our July/August issue. This month, our Upfront articles showcase early HIV detection, better cardiac risk prediction, and biomarkers for treatment response in cancer and depression. Our Feature continues the conversation on diagnostic error and how best to discuss and disclose it. NextGen reveals a novel portable digital microscope and brain growth charts that help spot neurodevelopmental disorders, and Profession tells pathologists how to place their discipline at the center of biomedical science. We Sit Down With Anthony Whetton, director of the Stoller Biomarker Discovery Center in Manchester, UK.