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August 2016 Issue of The Pathologist

Welcome to our July/August issue. This month, our Upfront articles showcase early HIV detection, better cardiac risk prediction, and biomarkers for treatment response in cancer and depression. Our Feature continues the conversation on diagnostic error and how best to discuss and disclose it. NextGen reveals a novel portable digital microscope and brain growth charts that help spot neurodevelopmental disorders, and Profession tells pathologists how to place their discipline at the center of biomedical science. We Sit Down With Anthony Whetton, director of the Stoller Biomarker Discovery Center in Manchester, UK.

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Articles featured in this issue

Outside the Lab Technology and innovation

Too Little, Too Late?

| Fedra Pavlou

Theranos is currently fighting for its life - but its story may not be over yet…

Outside the Lab Microbiology and immunology

The Secret Life of HIV

| Michael Schubert

Early-capture testing detects presymptomatic HIV infections for treatment and prevention

Inside the Lab Oncology

Revealing Recurrence Risk

| Michael Schubert

Deubiquitinating enzyme USP14 may predict endometrial cancer recurrence

Subspecialties Genetics and epigenetics

The Tell-Tale Gene

FCGR2A polymorphism can predict which colorectal cancer patients may respond to cetuximab

Subspecialties Precision medicine

Reading the Mind in the Blood

| Michael Schubert

Circulating inflammatory biomarker levels may hint at antidepressant effectiveness

Inside the Lab Microscopy and imaging

A Virtual Vision of the Future

| Michael Schubert

Noninvasive 3D modeling of damaged hearts can predict and prevent future arrhythmias

Outside the Lab Genetics and epigenetics

Putting a CAPN1 on HSP

| Michael Schubert

A new study shows that CAPN1 mutations may be causative for hereditary spastic paraplegia

Subspecialties Microscopy and imaging

Image of the Month

Macrophages are specialized phagocytic cells of the innate immune system that remove diseased cells and non-self objects from the body

Inside the Lab Histology

Only Gene Deep

| Han van Krieken

Advances in genomics are thrilling, but tumors aren't just bundles of genetic information

Outside the Lab Profession

To Err Is Human

| W. Greg Miller

One of the most pressing issues in laboratory medicine is lab test result harmonization

Outside the Lab Profession

Driving Down Diagnostic Discrepancies

| Raouf Nakhleh

Establishing a proactive strategy for case reviews could help reduce errors

Inside the Lab Profession

It’s Our Turn to Talk: Pathologists, Patients and Diagnostic Errors – Part II

How can pathologists explore the uncharted territory of diagnostic error disclosure?

Inside the Lab Profession

All in the Mind

What is actually going on in the mind when the decision-making process goes awry?

Inside the Lab Microscopy and imaging

Small, But Mighty

| Andrew Monk

Microscope portability doesn't always mean a compromise in image quality

Outside the Lab Neurology

Connecting the Dots to Developmental Disorders

| Daniel Kessler

Growth charts track formation of neural connections to identify patients at risk of ADHD

Subspecialties Profession

Restoring Pathology to its Former Glory

| Reinhard Büttner

Molecular pathology is key to our work; to stay relevant, pathologists must engage

Diagnostics Profession

Marker of Excellence

| Fedra Pavlou

Anthony Whetton, Director of the Stoller Biomarker Discovery Centre, Manchester, UK

Outside the Lab Profession

Liquid Biopsy and NGS: Teaming Up to Take Cancer Apart

| Nicola Normanno, Jose Machado

How liquid biopsy and next-generation sequencing fit into the pathology lab of the future

Other issues of 2016