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June 2021 Issue of The Pathologist

In June’s issue of The Pathologist, three proteomics experts talk to us about their work in the fight against COVID-19. How did they successfully use targeted proteomics for the detection of SARS-CoV-2 proteins? What role do proteomics play in aiding the fight against the pandemic? And where do structural and systems biology come into it? Also in this issue: how to ensure better health care for transgender patients, expanding the frontiers of precision medicine with macromolecules and machine learning, and the potential for 3D printing to reignite medical students’ interest in pathology. We also sit down with Pikka Jokelainen, Academic Officer at the Laboratory of Parasitology, Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark; Adjunct Professor of Zoonotic Parasitology at the University of Helsinki; President of the Scandinavian-Baltic Society for Parasitology; and Vice-President of the World Federation of Parasitologists.

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Articles featured in this issue

Outside the Lab COVID-19

A Season of Change

| Michael Schubert

The world has shifted on its foundations – and it’s time that people recognized the laboratory’s role in keeping it turning

Diagnostics Digital and computational pathology

Deep Learning Diagnostics for Barrett’s Esophagus

| Olivia Gaskill

A new machine learning algorithm triages Barrett’s esophagus diagnosis to detect early signs of esophageal adenocarcinoma

Diagnostics Analytical science

Testing for All

| Olivia Gaskill

A universal testing approach may help to detect hidden inherited mutations in colorectal cancer patients

Diagnostics Liquid biopsy

Saving the Spine with Serum Cytokines

| Olivia Gaskill

Reliably stratifying patients with spinal cord injury is essential for optimal treatment – and serum cytokines may be the key

Diagnostics Genetics and epigenetics

Rethinking Risk Stratification for Acute Lymphoblastic Leukemia

| Olivia Gaskill

Integrated pediatric leukemia risk stratification and relapse prediction

Diagnostics Genetics and epigenetics

Small Patients, Big Hearts

| Olivia Gaskill

Genetic testing for pediatric cardiomyopathy is recommended, but uptake varies between practices – new research supports the need for routine testing

Subspecialties Histology

Deep Blue Stain

| Dmitry A. Zinovkin

A new stain based on picro aniline, Ziehl’s fuchsin, and acetic acid offers a beautiful glimpse into the body

Subspecialties COVID-19

SARS-CoV-2 Variant Testing: AMP Guidance and Recommendations

| Olivia Gaskill

New guidance for sequencing and identifying SARS-CoV-2 variants has been released by the Association for Molecular Pathology

Diagnostics Histology

Case of the Month

A 60-year-old female presented with an intermittent cough and shortness of breath – but what is the diagnosis?

Subspecialties Forensics

An Ode to Autopsy

| Abdul Majeed Abid

Without these vital medical procedures, doctors would still be working in ignorance

Outside the Lab Profession

Medical Advocates of the Underserved

| Cesar Padilla

Integrating medical students into surrounding underserved communities may be the key to improving access to healthcare

Inside the Lab Guidelines and recommendations

Clinical Testing has Changed – Should CLIA?

| Robin Stombler

Is CLIA falling behind the ever-changing landscape of laboratory medicine? Robin Stombler suggests needed updates

Inside the Lab Clinical care

Labs in the Lead

| E. Blair Holladay

The laboratory lies at the heart of not just patient care, but also the research that gives our patients options for care

Inside the Lab Digital and computational pathology

A New Kind of Second Opinion from Diagnexia

| Sponsored by Diagnexia

Diagnostics Analytical science

The Call of Coronal Duty

| Lauren Robertson, Perdita Barran, Manfred Wuhrer, Jeroen Demmers

Jeroen Demmers, Perdita Barran, and Manfred Wuhrer walk us through the proteomics battlegrounds in the fight against COVID-19

Inside the Lab COVID-19

Understanding the Catalysts Behind the Acceleration of Digital Pathology

| Sponsored by Dell Technologies

Pathology is being radically transformed by digitization

Outside the Lab Profession

Driving Care for Our Trans Patients

| Timothy Craig Allen

Timothy Craig Allen and colleagues highlight the lab’s importance in providing appropriate health care for transgender patients

Inside the Lab Digital and computational pathology

Digital Pathology to Achieve the Quadruple Aim

| Monica Santamaria-Fries

Digital pathology is neither a replacement for, nor a supplement to, pathologists – it is a tool to help them improve their own working experience

Subspecialties Bioinformatics

RNA: The Villain… and the Hero

| Jarret Glasscock

Big data is key to precision medicine, but presents a stumbling block for analysis – can machine learning help us overcome this hurdle?

Inside the Lab Digital and computational pathology

From Pot to Print: Using 3D Scanning and Printing to Bring Back Pathology Specimens

| Paul G. McMenamin, Sarah E. Coupland, Justin W. Adams

Use of human anatomical pathology specimens is on the decline – but 3D printing may facilitate their safe and ethical comeback

Subspecialties COVID-19

A Way Forward with One Health

| Michael Schubert

Pikka Jokelainen introduces us to One Health, parasitology, veterinary medicine, and more

Other issues of 2021