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June 2016 Issue of The Pathologist

Welcome to the June issue. Our Upfront articles showcase viral infection visualization, new leukemia classifications, and the first-ever FDA approval of a liquid biopsy. Our Feature zeroes in on diagnostic error – and when and how to disclose it. In Practice walks readers through the ins and outs of breast cancer immunohistochemistry, and NextGen reveals a new approach to epigenetic control. Profession urges pathologists to get involved in medical education to stay relevant, and we Sit Down With Robert Weinberg, cancer biologist and research pioneer at MIT.

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Articles featured in this issue

Outside the Lab Profession

Is It Good to Talk?

| Fedra Pavlou

Pathologists are encouraged to speak up and be counted, but it’s not always that easy…

Outside the Lab Analytical science

An Electrifying Advance

| Michael Schubert

Electrical fields can modulate sample flow through lab-on-a-chip devices for greater precision

Diagnostics Microscopy and imaging

Virus Vision

| Michael Schubert

A new method uses fluorescent proteins to highlight virus-infected cells and shows which proteins are affected

Outside the Lab Analytical science

Simple Sample Sensing

| Carlos Cesar Bof Bufon

Carlos Cesar Bof Bufon explains the first phthalocyanine-based water-gated transistor for disease diagnosis

Outside the Lab Liquid biopsy

Liquid License

| Michael Schubert

FDA issues first-ever approval for liquid biopsy companion diagnostic

Outside the Lab Oncology

The 11 Faces of AML

| Michael Schubert

Classifying AML by genetic abnormalities may yield more accurate diagnosis, prognosis and treatment

Outside the Lab Profession

Fingerprick Fraud

| Michael Schubert

Founder Elizabeth Holmes admits that direct-to-consumer testing company Theranos’ technology doesn’t work – and wasn’t often used

Diagnostics Microbiology and immunology

Image of the Month

This series of sculptures by artist Rogan Brown, laser cut from paper and hand mounted into three-dimensional sculptural compositions, is an attempt to depict the diversity and beauty of the vast colony of organisms that live in and on the human body.

Outside the Lab Profession

Let’s Take Control

| Danielle Freedman

Laboratory professionals need to be involved in the total testing process to improve patient outcomes and avoid harm

Inside the Lab Analytical science

How to Succeed in MS

| Y. Victoria Zhang

Financial and personnel considerations for bringing mass spectrometry into the clinical laboratory

Inside the Lab Profession

We Need to Talk: Pathologists, Patients and Diagnostic Errors – Part I

We can argue about how many diagnostic errors happen each year, but we can’t deny that there are too many of them. And when one of those errors is ours, denial is especially inappropriate – but how many of us feel comfortable about a confessional with the patient? In the first installment of a two-part feature, we examine the difficulties around disclosure and communication of diagnostic errors.

Outside the Lab Profession

It’s Our Turn

| Michael Laposata

Michael Laposata, co-author of the IoM report, speaks out…

Diagnostics Technology and innovation

A One-Two Punch for Colon Cancer

| Michael Schubert

A new approach to colorectal cancer screening may increase both accuracy and patient compliance

Outside the Lab Histology

A Guide to IHC

| Ping Tang

How immunohistochemical analysis can help navigate the complexities of breast pathology

Diagnostics Genetics and epigenetics

The Impact of COMET

| Ralph Mazitschek, Stephen J. Haggarty

A new approach to epigenetic control may allow precise spatiotemporal targeting of disease-controlling mechanisms

Outside the Lab Profession

Avoiding the Ripple Effect

| Charles Matthew Quick

How can pathologists stay relevant? By taking an integrative approach to pathology education…

Subspecialties Profession

Oncogenetic Pioneer

| Charlotte Barker

Sitting Down With… Robert A. Weinberg, founding member of the Whitehead Institute for Biomedical Research and Professor of Biology at the Massachusetts Institute of Technology, USA.

Subspecialties Oncology

NGS: Driving a Revolution in Cancer Diagnostics and Treatment Management

The growing demand for multiple biomarker analysis is presenting diagnostics labs with many new challenges – do you outsource or adapt? And if you keep testing in-house, is the one test–one drug approach even sustainable? Possibly not…

Other issues of 2016