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April 2019 Issue of The Pathologist

In this month’s issue we ask a simple, but fascinating question: did dinosaurs get cancer? With the help of Mary Schweitzer, a molecular paleontologist, we investigate the soft tissues preserved in bones from millions of years ago to solve the medical mysteries of the Cretaceous. Then, read about a sensitive approach to monitoring AML relapse after bone marrow transplant, a project aiming to revolutionize cancer diagnostics through computational power, and how social media can ease the transition to digital pathology. We sit down with Bethany Williams, Leadership and Management Fellow in Digital Pathology at Leeds Teaching Hospitals NHS Trust, Leeds, UK.

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Articles featured in this issue

Diagnostics Genetics and epigenetics

Circular RNA Makes Its Mark

| Jason Sherburn

A new detection method enhances circular RNA’s potential as a cancer biomarker and forms the basis of a new database

Diagnostics Microbiology and immunology

Out With the Old

| Luke Turner

Existing tests for rapid diagnosis of TB are costly and insufficient – but second-generation assays with improved sensitivity could be the answer

Diagnostics Clinical care

Act Fast Against Infection

| Matthieu Legrand

To confront the increasing problem of antimicrobial resistance in medicine, laboratorians and clinicians must pursue rapid diagnostics

Inside the Lab Digital and computational pathology

Open to the Future

| Jane Rendall

If artificial intelligence is to make inroads into diagnostic medicine, we must embrace a new standard of openness and interoperability

Outside the Lab Digital and computational pathology

A Shared Path to Digital Pathology

| Felipe S. Templo, Jr.

As digital pathology comes ever closer, social media can help us hone our skills in preparation

Outside the Lab Profession

Becoming Our Best Through Continuing Education

| E. Blair Holladay

Constant updates to our knowledge are the key to staying at the top of our professional game

Diagnostics Hematology

Improving Our Early Warning System for AML

| Amanda Winters

The gold standard for monitoring acute myeloid leukemia relapse after bone marrow transplant is chimerism testing – but is it sensitive enough?

Subspecialties Oncology

TruSight™ Oncology 500: Enabling Comprehensive Genomic Profiling for Every Laboratory

| Sponsored by Illumina

Comprehensively exploring tumor samples to analyze hundreds of current and emerging cancer-related biomarkers

Inside the Lab Digital and computational pathology

Leading by Example

| Michael Schubert

Bethany Williams shares her experiences as the world’s first Leadership and Management Fellow in Digital Pathology

Outside the Lab Profession

An Ancient Inspiration

| Michael Schubert

How questions ranging from the conventional to the just-plain-weird can inspire careers in science and laboratory medicine

Diagnostics Hematology

Casting a Broader Net

| Luke Turner

Pancreatic cancer is associated with poor patient outcomes; could a new blood test improve screening accuracy for those at risk?

Diagnostics Analytical science

Unraveling the D-Amino Acid Mystery

| Luke Turner

D-serine has shown potential as a biomarker for the prediction of kidney function and the detection of chronic kidney disease

Subspecialties Forensics

CSI: Cretaceous

| Michael Schubert

The discovery of soft tissues and biomolecules preserved in ancient fossils opens up a new realm of studies linking paleontology with modern medicine

Inside the Lab Digital and computational pathology

A Real PAIGE-Turner

| Luke Turner

Paige.AI is developing deep learning algorithms to revolutionize cancer diagnostics

Subspecialties Microbiology and immunology

Spotting Sepsis Sooner

| Rachel Burnside

Sepsis kills millions and costs billions each year, but a new approach that analyzes morphological changes in monocytes could help

Inside the Lab Precision medicine

Next-Generation Sequencing: Will It Really Replace Single-Gene Tests in Pathology Labs?

| Sponsored by Thermo Fisher Scientific

The move to in-house next-generation sequencing has resulted in time and tissue savings, and improved collaboration across cancer care specialties

Diagnostics Clinical care

Case of the Month

Can you diagnose this male smoker in his 60s who presented with a lung mass?

Other issues of 2019