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April 2017 Issue of The Pathologist

Welcome to our April issue. Take our Case of the Month challenge with a uterine tumor resected from a 55-year-old woman, and check your answer from last month! Upfronts address novel types of biomarkers for cancer, organ transplant and mental illness. Emyr Benbow’s In My View calls for pathologists to involve themselves in integrated medical education – an excellent lead-in to our Feature on medical education, which deals with the transition from knowledge-based to competency-based training and introduces several experts who share their experiences, opinions, and top tips for teachers. Our In Practice section focuses on the importance of multi-omic studies for a complete picture of disease. In NextGen, we look at the value of previously dismissed “junk” genetic elements like long non-coding RNA SAMMSON, and Profession calls for greater reproducibility in scientific literature. We Sit Down With Ron Heeren, Director of the Maastricht MultiModal Molecular Imaging Institute.

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Articles featured in this issue

Outside the Lab Profession

Start Spreading the News

| Fedra Pavlou

Molecular diagnostics are booming, disease detection is on the rise: change is upon us

Subspecialties Histology

Case of the Month

Take a look at these uterine tumor slides to see if you can figure out the diagnosis

Inside the Lab Microbiology and immunology

Exosome Exploration

| William Aryitey

Exosomes may be the key to identifying noninvasive methods to spot transplant rejection

Diagnostics Oncology

From Neurobiology to Prostate Cancer Pathology

| William Aryitey

The drebrin/EB3 pathway: new therapeutic targets and biomarkers for prostate cancer

Inside the Lab Precision medicine

The Combination Question

| Michael Schubert

Could CRP guide clinicians when selecting antidepressant medication to prescribe?

Inside the Lab Neurology

Li Detector

| Michael Schubert

Determining the effectiveness of lithium therapy in bipolar disorder by observing neurons

Outside the Lab Oncology

Taking the EV Option

| William Aryitey

Could a cancer-diagnosing liquid biopsy technique lie within extracellular vesicles?

Inside the Lab Profession

How Do We Prove Our Worth?

| Michael Misialek

Pathologists must be facilitators of institutional change to deliver value-based care

Outside the Lab Training and education

As Education Changes, We Must Too

| Emyr Benbow

To make medical school relevant for future pathologists, we must involve ourselves

Diagnostics Precision medicine

Clinical Metabolomics: Will it Deliver?

Metabolomic biomarker detection strategies must take a new direction to succeed

Outside the Lab Profession

The Competency Changeover

| Michael Schubert

Medical education is no longer about what you know, but what you do with it

Outside the Lab Profession

Skill Switch

| Marcio Gomes

Pathology training in Canada is transitioning from knowledge-based to competency-based

Diagnostics Profession

The Slide and the Sequence

| Stephen Yip

Glass-based pathology is still vital, but nowadays, genomics is equally important

Outside the Lab Training and education

The Cornerstone of Competency

| Alexandra Wolanskyj

To effectively assess medical learning, we must use milestones of competency

Diagnostics Oncology

Toward Integrative Omics

| Amanda Hummon

Cancer is a complex disease, and no single -omic technique can give us a complete picture

Diagnostics Oncology

Omics in the Literature

What does analysis of the last 15 years of literature on the different omics tell us about the growing importance of the field

Diagnostics Genetics and epigenetics

The “One Pot” Approach

| Tom Metz

Protocols that allow multiple simultaneous -omic studies are the way of the future

Diagnostics Oncology

Buried Treasure

Long non-coding RNAs are far from "junk" - and some are key to cancer cell survival

Inside the Lab Training and education

Care To Repeat That?

| Ira Krull

Much of today's scientific literature contains unacceptable irreproducible experiments

Subspecialties Microscopy and imaging

Collaborating for the Clinical Win

Ron Heeren, Director of the Maastricht MultiModal Molecular Imaging Institute, The Netherlands

Other issues of 2017