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In this issue we explore how predatory journals and conferences often capitalize on the “publish or perish” culture within academia. How are these for-profit organizations able to manipulate researchers by charging hefty amounts without delivering the scientific rigor or stature they promise? And how can we address misaligned incentives in science and medicine to combat them? We answer these questions and investigate the telltale signs of predatory publishers to look out for. In addition, read about the importance of color calibration in digital pathology scanners, preventing the fatal contamination of biological products, and an interview with Benjamin Garcia, Presidential Professor of Biochemistry and Biophysics and Director of Quantitative Proteomics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.