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February 2016 Issue of The Pathologist

Welcome to the February issue. Our Upfront topics include a genetic basis for IVF failure, viral adaptations that cause pandemics, and a new method of resolving detailed 3D cell structures. Our Feature explores the depths of Alzheimer’s disease and what’s being done to promote prevention, early detection and treatment. NextGen looks at wearable telepathology devices, models for personalized medicine, and new diagnostic technologies for rare genetic disorders and common cervical cancers. In Profession, we discuss direct contact between pathologists and patients, and we Sit Down With Michael Laposata, Chairman of the Department of Pathology at the University of Texas Medical Branch at Galveston, Texas, USA.

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Articles featured in this issue

Inside the Lab Genetics and epigenetics

Crossing a Line in the Sand

| Fedra Pavlou

The UK has greenlit CRISPR-Cas9 gene editing in humans. Can and should it be controlled?

Inside the Lab Genetics and epigenetics

Fertilization Failure Forecast

| Michael Schubert

Understanding the genetic basis of recurrent IVF failure may help counsel couples.

Diagnostics Microbiology and immunology

Memory Modifications

| Michael Schubert

Epigenetic changes to memory T cell chromatin let them respond rapidly to re-infection.

Diagnostics Microbiology and immunology

Pandemic Protein

| Michael Schubert

The stability of a virus' hemagglutinin protein affects its potential to cause pandemics.

Diagnostics Cytology

Cracking the Case of Brittle Bones

| Michael Schubert

An excess of osteoclasts is the culprit behind brittle bones in Hajdu-Cheney syndrome.

Diagnostics Microbiology and immunology

Diversity’s Double-Edged Sword

| Michael Schubert

H. pylori's attachment protein contains a disulfide group that may be its downfall.

Subspecialties Microscopy and imaging

Breaking the Mold

| Michael Schubert

Diagnostic imaging may detect fungal lung infections faster and more accurately.

Outside the Lab Technology and innovation

Counting Chips

| Michael Schubert

A new microfluidic device may offer rapid, inexpensive blood counts from tiny samples.

Outside the Lab Analytical science

Cancer Polaroid

| Michael Schubert

A new nanomaterial might be the key to portable devices for detecting cancer recurrence.

Diagnostics Technology and innovation

The Secret Lives of Cells

| Michael Schubert

Mass spectrometry imaging can map cellular composition in unprecedented 3D resolution.

Diagnostics Genetics and epigenetics

The Next Generation

| Benoit Arveiler

We've come a long, long way already. Where to next for next generation sequencing?

Outside the Lab Digital and computational pathology

Color in Focus

| Elizabeth A. Krupinski

Color calibration paves the way to large-scale digital pathology rollout.

Subspecialties Profession

Unraveling Alzheimer's

| Charlotte Barker

Dementia is a uniquely terrifying prospect for most of us, more frightening even than the dreaded C word.

Outside the Lab Neurology

Untangling Tau

| Brad Hyman

Examining the genetic and neuropathophysiological factors in Alzheimer's disease.

Diagnostics Neurology

Iron's Influence

| James Connor

Iron's influence on neurodegenerative disease may support prevention or early diagnosis.

Inside the Lab Neurology

The Overactive Brain

| Michela Gallagher

Unusual neuron overactivity has led to a drug that may delay Alzheimer's disease onset.

Subspecialties Neurology

Food For Thought

| Ewan McNay

Insulin resistance in the brain adds a new dimension to Alzheimer's disease understanding.

Diagnostics Digital and computational pathology

Telepathology Heads Up

| Liron Pantanowitz

Revolutionary wearable devices show promise for improving pathology workflow.

Inside the Lab Precision medicine

Predicting the Impact of Personalization

| Neema Jamshidi

Kinetic models offer a single test to predicts patients' likelihood of drug side effects.

Outside the Lab Biochemistry and molecular biology

The Cathepsin Key

| Francis Gauthier, Brice Korkmaz

Urine cathepsin C testing may offer quicker, cheaper Papillon-Lefèvre syndrome detection

Outside the Lab Technology and innovation

Conquering the Challenges of Colposcopy

| Ursula Winters

A new diagnostic device may improve colposcopy and reduce the rate of cervical biopsy

Outside the Lab Profession

Interpersonal Pathology

| Marc Rosenblum

Pathologists' role in patient care should include speaking to patients about diagnoses.

Inside the Lab Profession

The Path(ology) to Quality Improvement

| Paul Stennett

What labs need to know about the importance of ISO 15189 accreditation.

Outside the Lab Profession

Rolling With the Punches

Michael Laposata, Chairman of Dept. of Pathology at University of Texas Medical Branch, Galveston, TX.

Other issues of 2016