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Welcome to the February issue. Our Upfront topics include a genetic basis for IVF failure, viral adaptations that cause pandemics, and a new method of resolving detailed 3D cell structures. Our Feature explores the depths of Alzheimer’s disease and what’s being done to promote prevention, early detection and treatment. NextGen looks at wearable telepathology devices, models for personalized medicine, and new diagnostic technologies for rare genetic disorders and common cervical cancers. In Profession, we discuss direct contact between pathologists and patients, and we Sit Down With Michael Laposata, Chairman of the Department of Pathology at the University of Texas Medical Branch at Galveston, Texas, USA.