Inside the Lab Microscopy and imaging, Microscopy and imaging, Histology, Microbiology and immunology, Oncology, Cytology, Neurology, Microbiology and immunology, Digital and computational pathology, Technology and innovation, Laboratory management

Through the Looking Glass

You take us on a journey through the beautiful world of pathology – the small, the stained, the simulated – through your own eyes in this gallery of images from all walks of laboratory medicine.

Michael Schubert | 09/22/2016

An explosive image of an intranasal fungal infection.

Alberto Berjón (@otromicroscopio)

A medical artist’s representation of osteoarthritis within the joints of the hand.

Francesca Corra

This electron micrograph shows remyelination in a case of chronic demyelinating polyneuropathy (biopsy taken from a 57-year-old woman).

Rosalind King

This mixed media image on paper shows surgical treatment of an acute aortic dissection.

David R S Evans, Cardiff University, Affiliate Member of the Medical Artists’ Association

This sample was fixed with glutaraldehyde, dehydrated with alcohol, and then critically point dried. After mounting on stubs, it was sputter-coated with gold for electron microscopy.

Glenn M Harper, Plymouth Electron Microscopy, University of Plymouth

3D reconstruction from 651 hematoxylin and eosin stained sections, in semi- translucent view, generated with microDimensions Voloom^®.

microDimensions

A small collection of electron micrographs of a photogenic Giardia lamblia selected from enterobiopsies.

Josef Špaček

This tissue section of an oral squamous cell carcinoma was scanned with whole- slide imaging and segmented, followed by Voronoi diagram calculation. Small polygons are mostly stromal cells, whereas larger polygons are epithelial cells from glands.

Martial Guillaud

A low power image showing a foot and mouth disease lesion in a section of bovine tongue. Blue: cell nuclei, green: actin filaments, red: foot and mouth disease virus.

Jennifer Simpson

This degenerative ophthalmic condition occurs when “asteroids” – calcium-lipid globules – accumulate in the vitreous humor of the eye, giving the appearance of stars in the night sky.

Natalie Cook

Enteropathogenic Escherichia coli grows actin “feet” to attach itself to the wall of the intestine, causing infection. Taken on a ZEISS field emission scanning electron microscope.

Manfred Rohde, HZI Braunschweig; ZEISS Microscopy

Coloured scanning electron micrograph of a ruptured venule running through fatty tissue. Stacked red blood cells (rouleaux formation) and white blood cells are seen within the venule.

Steve Gschmeissner (theworldcloseup.com)

A low power image showing the spread of foot and mouth disease virus in a porcine interdigital lesion. The necrotic region of the lesion is on the right; on the left are infected cells with normal epithelium. Blue: cell nuclei, red: foot and mouth disease virus.

Jennifer Simpson

Clockwise from top left: the rectification room, where plaster casts are carefully refined in the prosthetics department; the busy clinical chemistry laboratory; the histopathology laboratory; the cut- up room, as pathologists examine biopsies; PAPNET, a new cytologic screening technology under trial.

Julia Midgley; images from “Drawn From Experience” project except top, from “War Art and Surgery” project

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Michael Schubert

While obtaining degrees in biology from the University of Alberta and biochemistry from Penn State College of Medicine, I worked as a freelance science and medical writer. I was able to hone my skills in research, presentation and scientific writing by assembling grants and journal articles, speaking at international conferences, and consulting on topics ranging from medical education to comic book science. As much as I’ve enjoyed designing new bacteria and plausible superheroes, though, I’m more pleased than ever to be at Texere, using my writing and editing skills to create great content for a professional audience.